Science

Every major claim is substantiated by recent peer-reviewed research and industry white papers.

The Science Of Boosting Skincare Ingredient Efficacy

Important notes:

Several sources were cited multiple times for different aspects of the research
Some references represent meta-analyses combining multiple studies
Clinical studies referenced include both peer-reviewed research and industry-sponsored trials
Safety guidelines come from established medical organizations (AAD, Cleveland Clinic)
Recent 2024-2025 studies represent cutting-edge research in the field

Transdermal Drug Delivery & Heat Enhancement

PMC2700785 - "Transdermal drug delivery" - PubMed Central
PMC5818408 - "Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery" - NIH
ScienceDirect - "Thermodynamics of membrane transport and implications for dermal delivery"
PMC7817074 - "Enhancement strategies for transdermal drug delivery systems: current trends and applications" - NCBI

Red Light Therapy & Photobiomodulation

PMC5215870 - "Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy" - PubMed Central
PMC3926176 - "A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment" - PubMed Central
PMC10311288 - "Reverse skin aging signs by red light photobiomodulation" - PubMed Central
PMC5523874 - "Mechanisms and applications of the anti-inflammatory effects of photobiomodulation" - PubMed Central
Frontiers in Photonics - "Red-light photons on skin cells and the mechanism of photobiomodulation" (2024)

Vibration & Ultrasonic Enhancement

PMC3436072 - "Ultrasound-Mediated Transdermal Drug Delivery: Mechanisms, Scope, and Emerging Trends" - PubMed Central
PMC9528696 - "Vibration Therapy – A Clinical Commentary" - PubMed Central
PMC6560364 - "The Impact of Vibration Therapy Interventions on Skin Condition and Skin Temperature Changes" - NCBI

Massage & Lymphatic Drainage

PMC5383004 - "Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles" - PubMed Central
PMC10045879 - "The Utility of Lymphatic Massage in Cosmetic Procedures" - PubMed Central
Cleveland Clinic - "Lymphatic Drainage Massage: What It Is, What It Does & Whether You Need It"
ScienceDirect - "Effect of massage on retinol skin penetration"

Ingredient Penetration & Compatibility

PubMed - "Effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency"
PMC10873486 - "The Superior Effect of Radiofrequency With Targeted Ultrasound for Facial Rejuvenation by Inducing Hyaluronic Acid Synthesis" - PubMed Central
Biomedcentral - "Transdermal delivery systems in cosmetics" - Biomedical Dermatology
MDPI - "Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients"

Safety & Clinical Guidelines

American Academy of Dermatology - "Is red light therapy right for your skin?"
Cleveland Clinic - "Red Light Therapy: Benefits, Side Effects & Uses"
Cleveland Clinic - "LED Light Therapy: How It Works, Colors, Benefits & Risks"
Stanford Medicine - "Red light therapy: What the science says" (2025)

Recent Research (2024-2025)

Advanced Science (December 2024) - DPP-4 enzyme and stress-induced aging
Nature Communications (March 2024) - Photobiomodulation and cellular senescence
Journal of Cosmetic Dermatology (January 2024) - Acoustic cavitation lymphatic enhancement
Cell Reports (April 2024) - Heat-shock proteins and gene expression
International Journal of Cosmetic Science (March 2024) - Device-enhanced ingredient interactions

Industry & Commercial Sources

Project E Beauty - LED light therapy and serum compatibility
NuFACE - Microcurrent device technology and conductive gels
Red Light Therapy Home - Vitamin C and red light compatibility studies
Therabody Labs - Synergistic effects of heat, light, and mechanical stimulation
FoundMyFitness - Red light therapy research compilation

Medical & Clinical References

Journal of Clinical and Aesthetic Dermatology - Photodynamic therapy studies
International Journal of Molecular Sciences - Ultrasonic enhancement research
Photochemical & Photobiological Sciences - Cellular aging reversal studies
Biomedical Engineering Research - Multi-modal therapy sequencing

How To Access These Studies

PubMed Central (PMC) Sources:

Go to https://www.ncbi.nlm.nih.gov/pmc/ and search for these PMC numbers:

PMC2700785 - Transdermal drug delivery
PMC5818408 - Heat enhancement for transdermal delivery
PMC5215870 - Photobiomodulation mechanisms
PMC3926176 - Red light therapy controlled trial
PMC10311288 - Red light aging reversal
PMC5523874 - Anti-inflammatory photobiomodulation
PMC3436072 - Ultrasound transdermal delivery
PMC9528696 - Vibration therapy clinical commentary
PMC6560364 - Vibration therapy skin effects
PMC5383004 - Skin massage device effects
PMC10045879 - Lymphatic massage in cosmetics
PMC10873486 - Radiofrequency and hyaluronic acid
PMC7817074 - Transdermal enhancement strategies

Direct Journal Searches:

PubMed: https://pubmed.ncbi.nlm.nih.gov/
ScienceDirect: https://www.sciencedirect.com/
Nature Communications: https://www.nature.com/ncomms/
Frontiers in Photonics: https://www.frontiersin.org/journals/photonics

Medical Organization Sources:

Cleveland Clinic: Search their health library for "red light therapy" and "lymphatic drainage"
American Academy of Dermatology: https://www.aad.org/ - search for "red light therapy"
Stanford Medicine: Search for "red light therapy 2025"

Backed by Beauty & Health Experts

"Combining multiple dermatologist-approved technologies into one device can enhance treatment efficacy by addressing various skin concerns simultaneously. This integrated approach not only simplifies the skincare routine but also ensures that each technology complements the others, leading to improved skin health and appearance."

- Dr. Emily Harper,

Board Certified Dermatologist

“Facial cleansing brushes are a great way to get a deeper clean than just using your hands or a washcloth. Clair uses soft bristles to cleanse, making them the perfect choice for sensitive skin. This, combined with its LED and light therapy features, provides a full-stack solution for youthful beauty benefits.”

- Dr. Alexandra Bowles,

Board Certified Dermatologist

"There is no doubt that red and blue light can be very, very beneficial to skin. Red LED light stimulates the cells to create new energy and gives you more collagen, which decreases the depth of your wrinkles (even helping to shrink pore size). Blue light kills acne causing bacteria without drying.

- Dr. Rachel Nazarian,

Board Certified Dermatologist